NSCLC Treatment Option


TAFINLAR® (dabrafenib) capsules, in combination with MEKINIST® (trametinib) tablets, are prescription medications used to treat a type of lung cancer called NSCLC that has spread to other parts of the body (metastatic NSCLC), and that has a certain type of abnormal “BRAF V600E” gene. TAFINLAR, in combination with MEKINIST, should not be used to treat people with a type of lung cancer called wild-type BRAF NSCLC.


The first and only FDA-approved targeted treatment for BRAF V600E metastatic NSCLC

TAFINLAR + MEKINIST are prescription medicines in combination and is the first and only FDA-approved targeted treatment option for your BRAF V600E metastatic NSCLC.

Could TAFINLAR + MEKINIST be right for you?

Your health care provider will perform a biomarker test to make sure that TAFINLAR, in combination with MEKINIST, is right for you.

It is not known if TAFINLAR with MEKINIST is safe and effective in children.

Before starting NSCLC treatment

It is important to keep an open dialogue with your health care provider. Tell your health care provider about all of your medical conditions, including if you:

  • Have had bleeding problems or blood clots
  • Have stomach problems
  • Have inflammation of the colon
  • Have heart problems
  • Have eye problems
  • Have lung or breathing problems
  • Have high blood pressure (hypertension)
  • Have liver or kidney problems
  • Have diabetes
  • Are a man (including one who has had a vasectomy) with a female partner of reproductive potential
    • Men (including those who have had a vasectomy) should use condoms during sexual intercourse during treatment with TAFINLAR and MEKINIST and for at least 4 months after your last dose of TAFINLAR and MEKINIST
  • Plan to have surgery, dental, or other medical procedures
  • Have a deficiency of the glucose-6-phosphate dehydrogenase (G6PD) enzyme
  • Are pregnant or plan to become pregnant. TAFINLAR and MEKINIST can harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if TAFINLAR and/or MEKINIST passes into your breast milk