Understanding Side Effects


Side effects of TAFINLAR + MEKINIST

Serious side effects

As with many medications, you may experience some side effects while taking TAFINLAR + MEKINIST in combination. Below are possible side effects of treatment.

Taking TAFINLAR + MEKINIST may cause serious side effects, including:

New skin cancers, including cutaneous squamous cell carcinoma, keratoacanthoma, basal cell carcinoma, or melanoma

Inflammation of the intestines or tears (perforation) of the stomach or intestines

Heart problems, including heart failure

Lung or breathing problems

Serious skin reactions

Healthy red blood cells to break down too early in people with glucose-6-phosphate dehydrogenase deficiency

May increase the risk of a type of overactivity of the immune system (hemophagocytic lymphohistiocytosis) that can cause fever, swollen glands, bruising, or skin rash

Fertility problems

Bleeding problems

Blood clots

Eye problems


Increased blood sugar (hyperglycemia)

New or worsening high blood pressure (hypertension)

Low sperm counts

The most common side effects of TAFINLAR, in combination with MEKINIST, when used in patients with NSCLC include:





Diarrhea (call your health care provider if you get severe diarrhea)

Dry skin

Decreased appetite


Swelling of the face, arms, and legs




Shortness of breath


Talk to your health care provider about your side effects. These are not all the possible side effects of TAFINLAR + MEKINIST. Be sure to tell your health care provider about how you’re feeling or if you have any concerns about your treatment.