Understanding Side Effects

TAFINLAR + MEKINIST

Side effects of TAFINLAR + MEKINIST

Serious side effects

As with many medications, you may experience some side effects while taking TAFINLAR® (dabrafenib) capsules + MEKINIST® (trametinib) tablets in combination. Below are possible side effects of treatment.

Taking TAFINLAR + MEKINIST may cause serious side effects, including:

New skin cancers, including cutaneous squamous cell carcinoma, keratoacanthoma, basal cell carcinoma, or melanoma

Inflammation of the intestines or tears (perforation) of the stomach or intestines

Heart problems, including heart failure

Lung or breathing problems

Serious skin reactions

New or worsening high blood pressure (hypertension)

Fertility problems

Bleeding problems

Blood clots

Eye problems

Fever

Increased blood sugar (hyperglycemia)

Healthy red blood cells to break down too early in people with glucose-6-phosphate dehydrogenase deficiency

Low sperm counts

The most common side effects of TAFINLAR, in combination with MEKINIST, in patients with NSCLC include:

Fever

Dry skin

Chills

Fatigue

Decreased appetite

Bleeding

Nausea

Rash

Cough

Vomiting

Swelling of the face, arms, and legs

Shortness of breath

Diarrhea

 

Talk to your health care provider about your side effects. These are not all the side effects of TAFINLAR + MEKINIST. Be sure to tell your health care provider about how you’re feeling or if you have any concerns about your treatment.