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Understanding Side Effects

TAFINLAR + MEKINIST

As with many medications, you may experience side effects while taking TAFINLAR® (dabrafenib) capsules + MEKINIST® (trametinib) tablets. On this page you'll find some common side effects of treatment, as well as tips on how to manage them that your doctor may suggest.

Watch the video below to learn more about side effects associated with TAFINLAR + MEKINIST

Tips for Managing Common Side Effects

Managing Side Effects
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Fever is one of the most common side effects of treatment with TAFINLAR + MEKINIST combination therapy for BRAF+ advanced melanoma

When taking TAFINLAR + MEKINIST, fever may occur frequently or may be severe. In some cases, chills or shaking chills, too much fluid loss (called “dehydration”), low blood pressure, dizziness, or kidney problems can occur with the fever.

What to do if you think you may have a fever

As soon as you start feeling unusually warm or cold, check your temperature. Call your health care provider right away if you get a fever while taking TAFINLAR + MEKINIST. Your health care provider may recommend that you:

Tips for managing other common side effects

Talk to your health care provider right away if you experience any side effects. Your doctor may choose to modify, interrupt, or discontinue your dosage.

Additional common side effects:

  • Other common side effects include cough, nausea, chills, vomiting, high blood pressure (hypertension), and swelling of the face, arms, or legs

If you experience side effects, your doctor may decide to adjust your dose or stop TAFINLAR and/or MEKINIST.

Do not change your dose or stop TAFINLAR or MEKINIST unless your doctor tells you to.

Keep track of your side effects, and inform your doctor about any side effect that bothers you or that does not go away. Keep track of your side effects, and inform your doctor about any side effect that bothers you or that does not go away.