Because it is a combination treatment of 2 different medications with different strengths, it’s very important to understand how to take TAFINLAR + MEKINIST the right way.


The recommended dosage of TAFINLAR + MEKINIST is 2 capsules of TAFINLAR (the dark pink capsule) twice a day (4 capsules each day) + 1 tablet of MEKINIST (the light pink circular tablet) once a day (1 tablet each day).

Recommended daily dose of TAFINLAR® (dabrafenib) + MEKINIST® (trametinib)

Capsules and tablet shown are not actual size or likeness.


It’s also recommended you take the TAFINLAR doses about 12 hours apart. Since TAFINLAR + MEKINIST is an oral melanoma treatment, you’ll take it by mouth—at least 1 hour before or at least 2 hours after eating. Do not open, crush, or break TAFINLAR capsules.

Missed a dose of TAFINLAR + MEKINIST?

If you miss a dose of TAFINLAR and/or MEKINIST, take it as soon as you remember, unless:

  • You’ve missed TAFINLAR and it is within 6 hours of your next scheduled dose, or
  • You’ve missed MEKINIST and it is within 12 hours of your next scheduled dose

In either case, just take your next dose at the regular time. Do not make up for the missed dose.


It is important that you understand and follow your health care provider’s directions for taking TAFINLAR + MEKINIST. Do not change your dose or stop TAFINLAR or MEKINIST unless your health care provider tells you to.


  • Store TAFINLAR at room temperature, between 68 ºF to 77 ºF
  • Keep TAFINLAR and the drying agent (desiccant) in the original bottle to protect from moisture
  • Store MEKINIST in the refrigerator between 36 ºF to 46 ºF
  • Keep MEKINIST dry and away from moisture and light
  • The bottle of MEKINIST contains a packet that helps keep your medicine dry. Do not throw away this packet
  • Keep MEKINIST in the original bottle. Do not place tablets in a pill box
  • Safely throw away MEKINIST that is expired or no longer needed