Side Effect Management


Female NSCLC patient discusses TAFINLAR® (dabrafenib) + MEKINIST® (trametinib) side effect management with healthcare provider

As with many medications, you may experience possible side effects while taking TAFINLAR® (dabrafenib) capsules + MEKINIST® (trametinib) tablets. Below are some common side effects of TAFINLAR + MEKINIST treatment and tips your health care provider may suggest to help you manage them. Talk to your health care provider right away if you experience any side effects. Your health care provider may choose to modify, interrupt, or discontinue your dosage.

Common side effects of TAFINLAR and MEKINIST in people with NSCLC, include:

  • Fever
  • Fatigue
  • Nausea
  • Vomiting
  • Diarrhea
  • Dry skin
  • Decreased appetite
  • Rash
  • Swelling of the face, arms, and legs
  • Chills
  • Bleeding
  • Cough
  • Shortness of breath

Taking TAFINLAR + MEKINIST may cause serious side effects, including:

  • New skin cancers, including cutaneous squamous cell carcinoma, keratoacanthoma, basal cell carcinoma, or melanoma
  • Bleeding problems
  • Inflammation of the intestines, or tears (perforation) of the stomach or intestines
  • Blood clots
  • Heart problems, including heart failure
  • Eye problems
  • Lung or breathing problems
  • Fever
  • Serious skin reactions
  • Increased blood sugar (hyperglycemia)
  • New or worsening high blood pressure (hypertension)
  • Healthy red blood cells to break down too early in people with glucose-6-phosphate dehydrogenase deficiency
  • Fertility problems
  • Low sperm counts

How your health care provider may help you manage fever

Fever is a common side effect of TAFINLAR + MEKINIST combination therapy, but it may also be serious. When taking TAFINLAR + MEKINIST, fever may occur frequently or may be severe. In some cases, chills or shaking chills, too much fluid loss (called “dehydration”), low blood pressure, dizziness, or kidney problems can occur with the fever.

What to do if you think you may have a fever on treatment

As soon as you start feeling unusually warm or cold, check your temperature. Call your health care provider right away if you get a fever while taking TAFINLAR + MEKINIST.

Your health care provider may recommend that you:

Drink liquids (for example: water, soups, ice pops)

Get plenty of rest

Place a cold cloth on your forehead if you feel hot

Use over-the-counter antifever medicines such as acetaminophen or ibuprofen as needed according to your health care provider’s instructions


Tips your health care provider may suggest for managing other common side effects



Your health care provider may give you a range of recommendations, from limiting exposure to the sun to using a gentle, thick, alcohol-free emollient cream to soothe affected areas. In some cases these rashes and other skin reactions can be severe, and may need to be treated in a hospital.


Joint aches


Your health care provider may suggest over-the-counter nonsteroidal anti-inflammatory drugs to help relieve pain and swelling, along with icing and resting the affected area. 




Your health care provider may recommend a specific diet plan along with an increase in fluids and a decrease in greasy food, spicy foods, or foods containing dairy. In serious cases, diarrhea could be a sign of perforations of the stomach or intestines that can lead to death.


Keep track of your side effects, and inform your health care provider about any side effect that bothers you or that does not go away.


If you experience side effects, your health care provider may decide to adjust your dose or stop TAFINLAR and/or MEKINIST.

Do not change your dose or stop TAFINLAR or MEKINIST unless your health care provider tells you to.