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How to Take Treatment

TAFINLAR + MEKINIST

The information on this page will help you get a better idea of how and when to take TAFINLAR® (dabrafenib) capsules + MEKINIST® (trametinib) tablets. As you begin your treatment regimen for BRAF V600E metastatic NSCLC, it's important that you keep a list of all of your medicines and show it to your health care provider whenever you get a new medicine. Certain medicines may affect each other, causing side effects.

Before starting treatment, it is important to have a thorough conversation with your health care provider to ensure that your treatment with TAFINLAR + MEKINIST is right for you.

How should I take TAFINLAR?

  • Take TAFINLAR exactly as your health care provider tells you. Do not change your dose or stop TAFINLAR unless your health care provider tells you
  • Your health care provider may change your dose of TAFINLAR, temporarily stop, or completely stop your treatment with TAFINLAR if you develop certain side effects 
  • Take TAFINLAR 2 times a day, about 12 hours apart
  • Take TAFINLAR at least 1 hour before or 2 hours after a meal
  • Do not open, crush, or break TAFINLAR capsules
  • If you miss a dose of TAFINLAR, take it as soon as you remember. But if it is within 6 hours of your next scheduled dose, just take your next dose at your regular time. Do not make up for the missed dose

How should I take MEKINIST?

  • Take MEKINIST exactly as your health care provider tells you to take it. Do not change your dose or stop MEKINIST unless your health care provider tells you
  • Your health care provider may change your dose of MEKINIST, temporarily stop, or completely stop your treatment with MEKINIST if you develop certain side effects
  • Take MEKINIST one time a day, about every 24 hours
  • Take MEKINIST at least 1 hour before or 2 hours after a meal
  • If you miss a dose, take it as soon as you remember. If it is less than 12 hours before your next scheduled dose, skip the missed dose. Just take the next dose at your regular time

It is important that you understand and follow your health care provider’s directions for taking TAFINLAR + MEKINIST. Do not change your dose or stop TAFINLAR or MEKINIST, unless your health care provider tells you to.

Develop a routine for taking your medicine that fits your daily schedule. For example, you can take TAFINLAR + MEKINIST in the morning, 1 hour before breakfast, and then you can take TAFINLAR again in the evening, at least 2 hours after dinner. Develop a routine for taking your medicine that fits your daily schedule. For example, you can take TAFINLAR + MEKINIST in the morning, 1 hour before breakfast, and then you can take TAFINLAR again in the evening, at least 2 hours after dinner.