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Understanding Side Effects



Fever is a common side effect of TAFINLAR® (dabrafenib) + MEKINIST® (trametinib) combination therapy. When taking TAFINLAR + MEKINIST, fever may occur frequently or may be severe. In some cases, chills or shaking chills, too much fluid loss (called "dehydration"), low blood pressure, dizziness, or kidney problems can occur with the fever.

What to do if you think you may have a fever

As soon as you start feeling unusually warm or cold, check your temperature. Call your health care provider right away if you get a fever while taking TAFINLAR + MEKINIST. Your health care provider may recommend that you:

Tips your doctor may suggest for managing other common side effects

As with many medications, you may experience some side effects while taking TAFINLAR + MEKINIST. Below are some common side effects of TAFINLAR + MEKINIST treatment and tips your doctor may suggest to help you manage them. Talk to your health care provider right away if you experience any side effects. Your doctor may choose to modify, interrupt, or discontinue your dosage.

Track side effects

Keep track of your side effects, and inform your doctor about any side effect that bothers you or that does not go away.

Additional common side effects:

  • Other common side effects include cough, nausea, chills, vomiting, high blood pressure (hypertension), and swelling of the face, arms, or legs

If you experience side effects, your doctor may decide to adjust your dose or stop TAFINLAR and/or MEKINIST.

Do not change your dose or stop TAFINLAR or MEKINIST unless your doctor tells you to.